General
Links
The Cell Nucleus
- An extremely nice page. Discusses the general functions of the cell nucleus
and numerous other structures of the nucleus, including: the nuclear envelope,
nuclear lamina, nuclear pore complex, active transport, signaling, and more.
Also provides very nice images of the cell nucleus and its structures.
Additional links available.
The
Nucleus Ultrastructure - Begins with an outline of the discussion, scroll
down to find the actual discussion. A very detailed page about the
nucleus and the structures that it is made up of.
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Chromosomes
Composed of chromatin, which is two strands of helical DNA and its associated
proteins, called histones. During cell division, the DNA becomes tightly
wound around the histones to form structures called nucleosomes, which are
further coiled and packaged into the highly condensed chromosome.
The Genetic Location
Database - Ldb is a database for constructing fully integrated genetic
and physical maps.
The Dog Genome Project
- A study being performed by several institutions in which they are attempting
to map out the chromosomal genome of dogs.
Triplo-X-Syndrome Database - Discusses
how to gather information on the Triplo-X-Syndrome.
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Mitosis
In mitosis, the cell makes a duplicate copy of itself that contains the
same number of chromosomes as contained in the original. The somatic
(nonreproductive) cells of higher organisms divide by mitosis.
An
Introduction to Mitosis - A discussion on mitosis which is followed by
discussions on each individual step in the mitosis process (i.e. prophase,
metaphase
). Includes links to actual photographs of each step (the
images take a long time to down view, but are very nice).
Mitosis
and Meiosis - Provides a discussion on each individual step in the mitosis
process. This is followed by a discussion on meiosis, which includes information
on synapsis and crosssing over.
The
Cell Cycle & Mitosis Tutorial - An introduction to the cell cycle
and to mitosis.
An
Introduction to Mitosis - A fairly detailed discussion on the process
of mitosis.
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Meiosis
In meiosis, the cell divides twice, ultimately yielding four daughter
cells. The first division separates the homologous chromosomes so that the
resulting cells contain only half the number of chromosomes found in the
original cell. The second division separates sister chromatids (as in mitosis),
resulting in a total of four haploid cells.
Meiosis
- Provides a short description of meiosis I and meiosis II, including short
discussions on each stage. Also provides information on recombination,
crossing over, random assortment of homologues, and fertilization.
- Small, short animations on meiosis, mitosis, and a few other processes.
The Hawley Lab: Meiosis
- Discusses meiosis and the way in which it operates. Also provides some
examples of organisms whose meiosis mechanisms vary from the norm.
Cell
Reproduction - Includes short discussions on the meiotic cycle and animal,
plant, and fungal reproduction.
Meiosis and
Cytokinesis - An image of meiosis which is accompanied by a small
introduction of what is being viewed.
Meiosis
Tutorial - Provides valuable information for better understanding the
meiosis process.
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Transcription
Enzymes (RNA polymerases) interact with or "read" a sequence of DNA to
make an RNA version of the DNA (gene), often called an mRNA or transcript.
Basal
Transcription Factor Information - A very advanced research page. Provides
a brief introduction to basal transcription factors, followed by a database
of basal transcription factors.
Transcription
- Provides a brief overview of transcription.
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Splicing
In eukaryotic cells, after DNA is transcribed, the resulting RNA must
often be processed further by enzymes that remove or "splice" specific regions
of the sequence. By altering the splicing of each transcript, many different
polypeptides can result from one original DNA sequence.
Home Gene-Splicing Kit - An
advertisement for a fun little program which allows you to imitate gene splicing.
Provides a sample game.
Gene Splicing Commemorative
Stamp - A funny little image of a stamp developed in honor of gene splicing.
How to Splice a
Gene - Provides the procedure first used in performing gene splicing.
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Nucleolus
This is the region within the nucleus where rRNA is transcribed and combined
with proteins to make ribosomes. In this region, chromosomal DNA forms loops,
exposing the rRNA genes to be transcribed.
The Nucleolus
- A brief overview of the nucleolus. Provides a nice labeled
image.
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Some Labs
Sites
Paul Schedl
- The general goal of our research on Drosophila melanogaster is to gain
insights into some of the mechanisms governing the utilization of genetic
information in eukaryotes.
Meiosis Laboratory - Institute
of Cytology and Genetics, Russia.
Nuclear Architecture and
Chromosome Organization - Laboratory of John W. Sedat -research is aimed
at understanding the organization of chromosomes within the nucleus, the
detailed architecture of the chromosomes themselves, and the functional roles
this organization plays in determining chromosome behavior.
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